Expression of telomerase genes in mamary atypical ductal hyperplasia / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 30-33, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-328527
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of telomerase genes and the malignant transformation of atypical mammary ductal hyperplasia.</p><p><b>METHODS</b>Telomerase genes hTR and hTRT in 50 cases of mammary hyperplasia (the cases included 6 benign hyperplasia, 9 mild atypical hyperplasia, 12 medium atypical hyperplasia, 23 severe atypical hyperplasia) and 26 cases of breast carcinoma were detected by in situ hybridization.</p><p><b>RESULTS</b>The expression of hTR and hTRT mRNA were weak or negative in benign hyperplasia (1/6, 0), weaker in mild-moderate atypical hyperplasia (2/9, 1/9, 4/12, and 3/12), strong in severe atypical hyperplasia (14/23, 60.9% and 12/23, 52.1%), while very strong expression (23/26, 88.5% and 21/25, 80.8%) in carcinoma of the breast. The difference between mild-moderate atypical hyperplasia, invasive ductal carcinoma and severe atypical hyperplasia was significant (P < 0.05) and the difference between severe atypital hyperplasia and intraductal carcinoma was not significant (P > 0.05).</p><p><b>CONCLUSIONS</b>Telmerase genes (hTR, hTRT) expression is closely related to the malignant transformation of atypical hyperplasia. The reactivated telomerase may play a crucial role in the development of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Breast Neoplasms
/
RNA, Messenger
/
Gene Expression
/
Carcinoma, Intraductal, Noninfiltrating
/
Telomerase
/
DNA-Binding Proteins
/
Genetics
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2002
Type:
Article
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