Correlation between single nucleotide polymorphisms and hematological malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 250-254, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-328533
ABSTRACT
Single nucleotide polymorphisms (SNPs) are the 3rd generation of molecular genetic markers of human populations.SNPs determine the functional units of genes and the inherent characteristics of genetic variation, and reflect the individual phenotype, disease susceptibility and differences of response to drug and environmental factors. Hematological malignancy is a multi-gene genetic diseases, and involve in the role of multigenic susceptible genes. This review intends to introduce the single nucleotide polymorphisms and their relevant progress of research on hematologic malignancies, including the SNP of carcinogen-metabolizing enzymes genes, the SNP of DNA repair genes, the SNP of oncogenes and anti-oncogene genes, the SNP of drug-metabolizing enzyme genes and so on.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromosome Mapping
/
Hematologic Neoplasms
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article
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