Research advance on the pathogenesis of T-ALL induced by notch 1 activating mutations / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 242-245, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-328535
ABSTRACT
T-cell acute lymphoblastic leukemia (T-ALL) is the hematological malignancy of bone marrow characterized by the rapid proliferation and subsequent accumulation of immature T lymphocyte and mainly occurs in children and adolescents. In 1991, a kind of activating mutation of Notch 1 was found in a subset of T-ALL with chromosomal translocation t(7;9) for the first time. During the past 20 years since then, understanding of the relationship between Notch 1 activating mutation and T-ALL has been deepened and widened. This review briefly discusses the four main subtypes of Notch 1 activating mutations, also focuses on how these mutations change the normal signaling pathways and genes expression during their participation in the pathogenesis of T-ALL, and how these insights will promote the development of newly targeting therapies for patients with this aggressive form of leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptor, Notch1
/
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/
Genetics
/
Mutation
Type of study:
Etiology study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article
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