Relation of HLA-DRB1*15 with pathogenesis in 162 childhood cases of acute lymphoblastic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1507-1510, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-328611
ABSTRACT
To unravel the relation of HLA-DRB1*15 with childhood acute lymphoblastic leukemia (ALL), 162 childhood patients with ALL were selected for this investigation. 1 000 normal umbilical cord blood samples were used as control.HLA-DRB1*15 and HLA-DRB5* were typed by polymerase chain reaction (PCR) analysis. The relation of HLA-DRB1*15 with childhood ALL was studied by calculating the chi-square test and relative risk. The results showed that the antigen frequencies and allele frequencies of HLA-DRB1*15 in childhood patients with ALL were 40.12% and 22.62% respectively, while the antigen frequencies and allele frequencies of HLA-DRB1*15 in control were 30.80% and 16.81% respectively, there were significant difference between them (chi(2) = 5.560, p = 0.018, RR = 1.506). In conclusion, the antigen frequencies and allele frequencies of HLA-DRB1*15 in childhood patients with ALL were higher than those in control, so the HLA-DRB1*15 gene is one of the genetic risk factors for childhood ALL. These preliminary data may be useful for further study on the pathogenesis of childhood ALL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HLA-DR Antigens
/
Case-Control Studies
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2009
Type:
Article
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