Study of methylation of promoter of EYA1 gene in microtia / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 436-439, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-328653
ABSTRACT
<p><b>OBJECTIVE</b>To explore the methylation of CpG islands in promoter of eye absent gene 1 (EYA1) in microtia.</p><p><b>METHODS</b>The methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.</p><p><b>RESULTS</b>The methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.</p><p><b>CONCLUSIONS</b>Hypomethylation in microtia may be related to the pathogenesis of the disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Congenital Abnormalities
/
Nuclear Proteins
/
Promoter Regions, Genetic
/
Protein Tyrosine Phosphatases
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
CpG Islands
/
DNA Methylation
/
Intracellular Signaling Peptides and Proteins
/
Ear
/
Genetics
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS