The relationship of angiotensin I-converting enzyme gene polymorphism with diabetic retinopathy and diabetes myocardial infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 283-285, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-328896
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of angiotensin I-converting enzyme (ACE) gene polymorphism to diabetic retinopathy and diabetes myocardial infarction.</p><p><b>METHODS</b>ACE insertion/deletion(I/D) polymorphism was determined by PCR.</p><p><b>RESULTS</b>No evidence showed that ACE gene was associated with diabetic retinopathy. By comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).</p><p><b>CONCLUSION</b>Allele D(RR=1.50) and genotype DD(RR=1.33) seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Risk Factors
/
Peptidyl-Dipeptidase A
/
Diabetes Mellitus, Type 2
/
Diabetic Retinopathy
/
Genetics
/
Myocardial Infarction
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2004
Type:
Article
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