Low and maternal-specific expression of p57KIP2 in hydatidiform mole and its clinical implication / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 121-157, 2002.
Article
in English
| WPRIM
| ID: wpr-329165
ABSTRACT
In situ hybridization was applied to locate and detect the expression of p57KIP2 in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57KIP2 expression were analyzed by HPIAS-1000 Image-Analysis System. p57KIP2 was highly expressed in normal villi but showed distinct low expression in hydatidiform mole (P < 0.01). Furthermore, the locus of low expression of p57KIP2 accorded with the place where lesion of trophoblast occurred. Detection of p57KIP2 made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57KIP2 could be a molecular marker in hydatidiform mole and a target for therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Uterine Neoplasms
/
RNA, Messenger
/
Nuclear Proteins
/
Hydatidiform Mole
/
Genomic Imprinting
/
Cyclin-Dependent Kinases
/
Enzyme Inhibitors
/
Cyclin-Dependent Kinase Inhibitor p57
/
Genetics
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS