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Effects of Biejiajian Pills on Wnt signal pathway signal molecules β-catenin/TCF4 complex activities and downstream proteins cyclin D1 and MMP-2 in hepatocellular carcinoma cells / 南方医科大学学报
Journal of Southern Medical University ; (12): 1758-1762, 2014.
Article in Chinese | WPRIM | ID: wpr-329206
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Biejiajian Pills on Wnt signal pathway and the mechanisms underlying its action to suppress the invasiveness of hepatocellular carcinoma.</p><p><b>METHODS</b>HepG2 cells cultured in the serum of rats fed with Biejiajian Pills for 48 h were examined for β-catenin expression using immunofluorescence, β-catenin/TCF4 complex activity with luciferase, and expressions of the downstream proteins cyclin D1 and MMP-2 using qRT-PCR.</p><p><b>RESULTS</b>Biejiajian Pills-treated sera significantly reduced the expressions of cytoplasmic and nuclear β-catenin protein, cyclin D1 and MMP-2 proteins and lowered the activities of β-catenin/TCF4 complex.</p><p><b>CONCLUSION</b>Biejiajian Pills may serve as a potential anti-tumor agent, whose effect might be mediated by inhibiting the Wnt/β-catenin pathway.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Transcription Factors / Drugs, Chinese Herbal / Carcinoma, Hepatocellular / Cyclin D1 / Matrix Metalloproteinase 2 / Wnt Proteins / Beta Catenin / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Hep G2 Cells Limits: Animals / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Transcription Factors / Drugs, Chinese Herbal / Carcinoma, Hepatocellular / Cyclin D1 / Matrix Metalloproteinase 2 / Wnt Proteins / Beta Catenin / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Hep G2 Cells Limits: Animals / Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article