Diagnostic value of urine HBV DNA for hepatitis B virus-associated glomerulonephritis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1705-Insidebackcover, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329216
ABSTRACT
<p><b>OBJECTIV</b>To investigate the potential value of urine hepatitis B virus (HBV) DNA as a new noninvasive diagnostic indicator for HBV-associated glomerulonephritis (HBV-GN).</p><p><b>METHODS</b>A total of 152 patients including 66 with HBV-GN, 66 with non-HBV-GN, and 20 with chronic hepatitis B (CHB) without renal disease were examined for serum and urine HBV DNA levels using polymerase chain reaction (PCR) and for 5 serum HBV markers using enzyme-linked immunosorbent assays.</p><p><b>RESULTS</b>Twenty-two patients (33%) in the HBV-GN group, but none in the other two groups, were found positive for urine HBV DNA. In the diagnosis of HBV-GN, urine HBV DNA had a high specificity (0.98), a good positive predictive value (PPV, 0.96), and a modest negative predictive value (NPV, 0.60). Urine HBV DNA, alone or in combination with serum HBeAg, was superior in the diagnosis of HBV-GN to the combination of urine HBV DNA with serum HBV DNA, hepatitis B surface antigen and the hepatitis B e antigen.</p><p><b>CONCLUSION</b>Urine HBV DNA may be one of the new noninvasive diagnostic criterion for HBV-GN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Virology
/
Blood
/
DNA, Viral
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Polymerase Chain Reaction
/
Predictive Value of Tests
/
Sensitivity and Specificity
/
Hepatitis B, Chronic
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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