Resveratrol enhances radiosensitivity of human hypopharyngeal carcinoma cell line in nude mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1646-1649, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329230
ABSTRACT
<p><b>OBJECTIVE</b>To study the radiosensitizing effect of resveratrol on human hypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice.</p><p><b>METHODS</b>Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining.</p><p><b>RESULTS</b>The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups.</p><p><b>CONCLUSION</b>Resveratrol can produce a radiosensitizing effect on human hypopharyngeal carcinoma in nude mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Radiation Effects
/
Radiation-Sensitizing Agents
/
Radiation Tolerance
/
Radiotherapy
/
Stilbenes
/
Transplantation, Heterologous
/
Carcinoma, Squamous Cell
/
Hypopharyngeal Neoplasms
/
Cell Line, Tumor
Type of study:
Controlled clinical trial
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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