Effect of acute exposure to high altitude on pharmacokinetics of propranolol and metoprolol in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1616-1620, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329236
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of propranolol and metoprolol in rats after acute exposure to high altitude.</p><p><b>METHODS</b>Wistar rats were randomly assigned into 4 groups for treatment with intragastric administration of propranolol or metoprolol after acute exposure to high altitude (4010 m) or normal altitude (50 m). Venous blood samples were collected from the rats at different time points after drug administration to determine the drug concentrations in the plasma and plasma ultrafiltrate using liquid chromatography-mass spectrometry (LC-MS/MS).</p><p><b>RESULTS</b>The protein binding rate of propranolol was significantly increased but that of metoprolol remained unchanged after acute exposure to high altitude. Compared with the rats exposed to normal altitude, the rats with acute exposure to high altitude showed significant alterations in the pharmacokinetic parameters of the drugs, shown by increased Cmax and AUC, prolonged t1/2 and MRT, and lowered Clz/F of propranolol, and by increased Tmax and prolonged t1/2 and MRT of metoprolol without obvious changes of the parameters of the compartmental model.</p><p><b>CONCLUSION</b>Significant changes in the pharmacokinetics of propranolol and metoprolol occur in rats after acute exposure to high altitude possibly in relation to, apart from the changes in plasma protein binding ratio and blood gas, alterations in metabolic enzyme activities, increased blood viscosity, and species and general conditions of the animals.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propranolol
/
Protein Binding
/
Pharmacokinetics
/
Chromatography, Liquid
/
Rats, Wistar
/
Tandem Mass Spectrometry
/
Altitude
/
Metoprolol
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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