Expression of mucin 15 in hepatocellular carcinoma and its clinical implications / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1611-1615, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329237
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of mucin 15 (MUC15) in hepatocellular carcinoma and explore its association with the prognosis of patients.</p><p><b>METHODS</b>The expression of MUC15 was detected by quantitative RT-PCR and Western blotting in liver cell line L02, liver cancer cell lines HepG2, MHCC-97H, and SMMC-7721, and in 122 HCC and corresponding adjacent non-tumor liver tissues. The association of MUC15 expression in HCC tissues with the clinical parameters and the patients' survival was analyzed.</p><p><b>RESULTS</b>The 1iver cell line L02 showed significantly higher MUC15 expression level than the liver cancer cell lines HepG2, MHCC-97H, and SMMC-7721 (P<0.05). The expression level of MUC15 was markedly lower in the HCC tissues than in the adjacent non-tumor liver tissues (P<0.05). MUC15 expression in the HCC tissues was significantly correlated with the tumor TNM stage, intrahepatic or lymphatic metastasis, portal vein thrombosis and tumor differentiation (P<0.05). Kaplan-Meier survival analysis suggested that a low MUC15 expression was associated with a poor clinical prognosis of the patients.</p><p><b>CONCLUSION</b>The expression of MUC15 is correlated with the clinicopathological features and prognosis of HCC patients, and may potentially serve as a novel prognostic marker for HCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Carcinoma, Hepatocellular
/
Cell Line, Tumor
/
Kaplan-Meier Estimate
/
Hep G2 Cells
/
Liver Neoplasms
/
Lymphatic Metastasis
/
Metabolism
/
Mucins
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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