Differential expression of midkine and Ki67 in gastric carcinoma and the clinical implications / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1534-1540, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329252
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of midkine (MK) and Ki67 in gastric carcinoma (GC) and their relation with the clinicopathologic characteristics.</p><p><b>METHODS</b>The expressions of MK and Ki67 in 71 GC and 20 adjacent normal tissues were evaluated by immunohistochemistry.</p><p><b>RESULTS</b>The expressions of MK and Ki67 were significantly higher in GC than in adjacent normal tissues (76.1% vs 0, and 73.2% vs 5%, respectively, P<0.05). MK and Ki67 expressions were correlated with the infiltration depth, lymph node metastasis and TNM stage (P<0.05), and a significant correlation was found between MK and Ki67 expressions (P<0.05).</p><p><b>CONCLUSION</b>GC tissues have high expressions of MK and Ki67, indicating that MK and Ki67 play important roles in promoting the tumorigenesis and progression of GC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Immunohistochemistry
/
Cytokines
/
Disease Progression
/
Ki-67 Antigen
/
Lymphatic Metastasis
/
Metabolism
/
Nerve Growth Factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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