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Establishment of blood β-hydroxybutyrate threshold for diagnosis of type 2 diabetes ketoacidosis / 南方医科大学学报
Journal of Southern Medical University ; (12): 1507-1510, 2014.
Article in Chinese | WPRIM | ID: wpr-329258
ABSTRACT
<p><b>OBJECTIVE</b>To establish of blood beta hydroxybutyrate (βOHB) threshold for diagnosing type 2 diabetes ketoacidosis (DKA) and explore the relationship between βOHB levels and the severity of DKA.</p><p><b>METHODS</b>Correlation analysis was performed between serum βOHB and [HCO(3)] in type 2 diabetic patients admitted in the emergency department in the past year. Regression equation was used to calculate the concentration of βOHB corresponding to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L, and βOHB concentration corresponding to a [HCO(3)] level of 18.0 mmol/l was used as the DKA diagnostic threshold.</p><p><b>RESULTS</b>The serum βOHB level and [HCO3] concentration showed a good correlation (R²=0.7023, P<0.001). βOHB concentrations that corresponded to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L were 3.0, 4.70, and 7.5 mmol/L, respectively, in accordance with the severity of DKA. Combined with the blood glucose concentration ≥ 13.9 mmol/L, a blood βOHB≥3.0 mmol/L showed a sensitivity of 99%, specificity of 86%, and total effectiveness of 92.81% for diagnosing DKA.</p><p><b>CONCLUSION</b>A serum βOHB level above 3.0 mmol/L can be used as the diagnostic threshold of DKA. βOHB can serve as an index for assessing the severity of DKA.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Severity of Illness Index / Sensitivity and Specificity / Diabetic Ketoacidosis / 3-Hydroxybutyric Acid / Diabetes Mellitus, Type 2 / Diagnosis Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Severity of Illness Index / Sensitivity and Specificity / Diabetic Ketoacidosis / 3-Hydroxybutyric Acid / Diabetes Mellitus, Type 2 / Diagnosis Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article