Establishment of blood β-hydroxybutyrate threshold for diagnosis of type 2 diabetes ketoacidosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1507-1510, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329258
ABSTRACT
<p><b>OBJECTIVE</b>To establish of blood beta hydroxybutyrate (βOHB) threshold for diagnosing type 2 diabetes ketoacidosis (DKA) and explore the relationship between βOHB levels and the severity of DKA.</p><p><b>METHODS</b>Correlation analysis was performed between serum βOHB and [HCO(3)] in type 2 diabetic patients admitted in the emergency department in the past year. Regression equation was used to calculate the concentration of βOHB corresponding to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L, and βOHB concentration corresponding to a [HCO(3)] level of 18.0 mmol/l was used as the DKA diagnostic threshold.</p><p><b>RESULTS</b>The serum βOHB level and [HCO3] concentration showed a good correlation (R²=0.7023, P<0.001). βOHB concentrations that corresponded to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L were 3.0, 4.70, and 7.5 mmol/L, respectively, in accordance with the severity of DKA. Combined with the blood glucose concentration ≥ 13.9 mmol/L, a blood βOHB≥3.0 mmol/L showed a sensitivity of 99%, specificity of 86%, and total effectiveness of 92.81% for diagnosing DKA.</p><p><b>CONCLUSION</b>A serum βOHB level above 3.0 mmol/L can be used as the diagnostic threshold of DKA. βOHB can serve as an index for assessing the severity of DKA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Severity of Illness Index
/
Sensitivity and Specificity
/
Diabetic Ketoacidosis
/
3-Hydroxybutyric Acid
/
Diabetes Mellitus, Type 2
/
Diagnosis
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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