Sequence polymorphisms of the mitochondrial DNA control region in 100 Chengdu Hans in China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 144-148, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-329380
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic polymorphisms of the mitochondrial DNA (mtDNA) control region in Chengdu Han population.</p><p><b>METHODS</b>Sequence polymorphisms of the mtDNA control region, hypervariable regions I and II from 100 unrelated Chinese Hans were determined by PCR and direct sequencing.</p><p><b>RESULTS</b>Sequences of 404 nucleotides for hypervariable region I and 379 nucleotides for region II were obtained. Ninety-two and fifty variable sites were revealed in region I and region II respectively as compared to the reference sequence, and a total of 97 different genetic patterns from both the regions I and II were determined. The probability of identity was estimated at 1.84% for region I, 1.94% for region II, and 1.18% for both the regions.</p><p><b>CONCLUSION</b>These results suggest that sequence polymorphism of mtDNA control region would be very useful in forensic practice as a marker for individual identification.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
DNA, Mitochondrial
/
Molecular Sequence Data
/
Base Sequence
/
Chemistry
/
China
/
Genetics, Population
/
Mutation
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2004
Type:
Article
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