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Clinical and experimental study of 38 cases with trisomy 8 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 528-531, 2003.
Article in Chinese | WPRIM | ID: wpr-329419
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of trisomy 8 in pathogenesis and progression of hematologic disease with trisomy 8.</p><p><b>METHODS</b>The clinical data on 38 cases with trisomy 8 were investigated retrospectively. Fluorescence in situ hybridization (FISH) using Spectrum Orange labeled chromosome 8 centromere specific probe was carried out to detect trisomy 8 in 10 cases.</p><p><b>RESULTS</b>Thirty-two of 38(84.2%) cases with trisomy 8, and fourteen of 17(82.4%) cases with trisomy 8 as the sole chromosome aberration were myeloid disorders such as myelodysplastic syndrome (MDS), acute myelocytic leukemia (AML), chronic myelocytic leukemia (CML). The incidence of trisomy 8 was higher in myeloid disease than in lymphocytic disease (5% vs 1.3%); the incidence of trisomy 8 was higher in acute monocytic leukemia than in other AML (6.1% vs 2.4%), and the incidence of trisomy 8 in chronic myelomonocytic leukemia( CMML) was higher than that in other myelodysplastic syndrome (MDS) (25% vs 13.2%); 17 cases had trisomy 8 as the sole chromosome aberration, 21 cases had other additional chromosome aberrations. The chromosome aberration was confirmed by FISH in 10 cases with trisomy 8 as the sole chromosome aberration. Eleven cases were treated with chemotherapy, among them only 10 cases data were available. Seven cases acquired complete remission but 3 of them were M3, the other 3 cases had no response after two courses of chemotherapy.</p><p><b>CONCLUSION</b>Trisomy 8 may play an important role in the pathogenesis and progression of the hematological disease, especially myeloid disease. Trisomy 8 might be related with differentiation abnormality of monocyte.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Trisomy / Myelodysplastic Syndromes / Chromosomes, Human, Pair 8 / Leukemia / In Situ Hybridization, Fluorescence / Genetics Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Trisomy / Myelodysplastic Syndromes / Chromosomes, Human, Pair 8 / Leukemia / In Situ Hybridization, Fluorescence / Genetics Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2003 Type: Article