Polymorphism of c-Ha-ras 3'VNTR in hydatidiform mole and its relationship with the development of postmolar tumor / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the polymorphism of c-Ha-ras 3' variable number of tandem repeat (VNTR) and its relationship with development of postmolar tumor.</p><p><b>METHODS</b>The cases of hydatidiform mole (HM) were retrospectively analyzed by amplified fragment length polymorphism-polyacrylamide gel electrophoresis. The DNA origin of HM was determined by comparison with the parents' DNA amplified results.</p><p><b>RESULTS</b>Among the samples from 15 cases, DNA from only paternal origin was found in 2 cases. DNA from both parents was in 13 cases, and of these 13 cases, 2 were found to be had balanced DNA origin, 11 had more DNA form paternal origin than DNA from maternal origin.</p><p><b>CONCLUSION</b>The HM which has DNA from both parents origin and predominantly from paternal origin developed to postmolar tumor more frequently.</p>