The distribution of angiotensin converting enzyme gene I/D polymorphism and its relationship with essential hypertension / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 438-440, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-329440
ABSTRACT
<p><b>OBJECTIVE</b>To observe the distribution character of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in Chinese population and its relationship with essential hypertension.</p><p><b>METHODS</b>Polymerase chain reaction (PCR) technique was used to detect the angiotensin converting enzyme gene I/D polymorphism in 2966 subjects of Kailuan Coal Mine, and further restriction analysis was performed.</p><p><b>RESULTS</b>The frequencies of ACE II, ID, DD genotypes in total study population were 41.5%, 38.4%, 20.1%, respectively. The DD genotypes in hypertensive group and that in control group were 18.9% and 21.0%, respectively. There was no significant difference between hypertensive group and control group (P>0.05). The same result was seen after stratification by age and gender in each group, respectively(P>0.05). The DD genotype and D allele showed a tendency to decrease with the increase of age (P<0.001).</p><p><b>CONCLUSION</b>The above results suggested that essential hypertension was not associated with ACE I/D polymorphism. The distributions of ACE genotype and allele varied with age, and the subjects with the character of DD genotype were at higher risk of early death.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Sex Factors
/
Age Factors
/
Peptidyl-Dipeptidase A
/
Gene Frequency
/
Genetics
/
Genotype
/
Hypertension
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2003
Type:
Article
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