A seroepidemiologic analysis of hepatitis B in Sichuan province / 中华流行病学杂志

ABSTRACT

Objective To understand the changes of hepatitis B infection rates,before and after the hepatitis B vaccine Was included into EPI.and to evaluate the effect of immunization which would lead to the development of a more appropriate hepatitis B control strategy.Methods Seroepidemiologic method,with multi-section random sampling method were chosen.14 sites from 8 counties were involved.2-4 ml of the vein blood was drawn from all the individuals engaged in the study including 3806 samples.HBsAg,anti-HBs.anti-Hbe of the samples were tested with ELISA.Results Standardized positive rates of HBsAg and HBsAb were found as 7.05%and 29.77%respectively with the overall infection rate of HBV as 40.30%.The hepatitis B vaccine coverage of the children under 15 years was 70.73%and the positive rates for both HBsAg and anti-HBS were 2.62%and 56.68%.respectively.The coverage of hepatitis B vaccine among children under 3 years was 83.44%and the positive rates of both HBsAg and anti-HBs were 1.47%and 67.69%respectively.hepatitis B vaccine coverage of children under 3 years was 85.77%.with positive rates of HBsAg and anti-HBs as 1.78%and 75.44%respectively.Conclusion Results from our study revealed that since the introduction of hepatitis B vaccination,the prevalence rates of HBsAg and HBV infeetion had an obvious decline,especially in children aged under 15 years of old,suggesting that some changes had occurred in the epidemic characteristics ofhepatitis B in Sichuan.