Meta-analysis on the relationship between colorectal cancer and Helicobacter pylori infection / 中华流行病学杂志

ABSTRACT

Objective Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter priori ififection by means of Meta-analysis.Methods To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2,calculating the odds ratio and 95% confidence interval,then drawing funnel plot.Results The total sample size is 3165,cases and controls are 1330 and 1835,respectively.The pooled OR is 1.36,and 95% confidence interval 1.01,1.82.The graphical funnel plot appearing asymmetrical,but analyzing by sensitivity analysis and fail-safe number calculation.The results are affected by publication bias.Conclusion The results of our Meta-analysis show that Helicobacter priori infection is a possible risk of colorectal cancer.