Comparative study on schizontocidal activity of recrystallized or crude daphnetin against malaria parasites / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 397-401, 2004.
Article
in English
| WPRIM
| ID: wpr-329621
ABSTRACT
<p><b>OBJECTIVE</b>To compare the schizontocidal activity of recrystallized or crude daphnetin against malaria parasites in vivo.</p><p><b>METHODS</b>Schizontocidal activity of recrystallized or crude daphnetin at various dosages was assessed in mice infected with Plasmodium berghei ANKA using a "4-day suppress assay".</p><p><b>RESULTS</b>The comparison of the reduction rate of parasitemia caused by either recrystallized or crude dephnetin showed that ED(50) of crude daphnetin was 18.36 mg/kg, with 95% confidence limit of 5.96-56.54 mg/kg while ED50 of recrystallized daphnetin was 11.46 mg/kg, with 95% confidence limit of 8.63-15.22 mg/kg.</p><p><b>CONCLUSION</b>The results indicate that the efficacy of recrystallized daphnetin is 37.6% higher than that of crude daphnetin.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parasitology
/
Pharmacology
/
Plasmodium berghei
/
Umbelliferones
/
Chromatography, High Pressure Liquid
/
Parasitic Sensitivity Tests
/
Dose-Response Relationship, Drug
/
Drug Therapy
/
Malaria
/
Antimalarials
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2004
Type:
Article
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