May chronic childhood constipation cause oxidative stress and potential free radical damage to children? / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 266-272, 2004.
Article
in English
| WPRIM
| ID: wpr-329636
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether chronic childhood constipation (CCC) may cause oxidative stress and potential free radical damage to children, and to explore the mechanisms by which CCC may cause oxidative stress and potential free radical damage to chronic constipation patients (CCPs).</p><p><b>METHODS</b>Sixty CCPs and sixty healthy child volunteers (HCVs) whose ages, gender and others were matched for the CCPs were enrolled in a randomized controlled study, in which levels of vitamin C (VC) and vitamin E (VE) in plasma as well as activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes were determined by spectrophotometric analytical methods.</p><p><b>RESULTS</b>Compared with average values of the above biochemical parameters in the HCVs group, the average values of VC and VE in plasma as well as those of SOD and CAT in erythrocytes in the CCPs group were significantly decreased (P < 0.0001). Linear regression and bivariate correlation analysis showed that with prolonged course of the CCPs, the levels of VC and VE in plasma as well as the activities of SOD and CAT in erythrocytes in the CCPs were decreased gradually (P < 0.0001).</p><p><b>CONCLUSION</b>The findings in the present study suggest that chronic childhood constipation causes oxidative stress and potential free radical damage to children with chronic constipation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ascorbic Acid
/
Superoxide Dismutase
/
Time Factors
/
Vitamin E
/
Blood
/
Catalase
/
Random Allocation
/
Case-Control Studies
/
China
/
Epidemiology
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2004
Type:
Article
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