Polymorphisms of renin-angiotensin system in essential hypertension in Chinese Tibetans / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 209-216, 2004.
Article
in English
| WPRIM
| ID: wpr-329640
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the potential implications of the genetic variability of angiotensin converting enzyme, angiotensinogen and angiotensin II type 1 receptor gene for essential hypertension in Tibetan.</p><p><b>METHODS</b>A case-control study was conducted in 173 hypertensive individuals and 193 individuals with normal blood pressure. Multiple logistic regression analyses were used to estimate the risks of developing hypertension for different genotypes, and haplotype analyses of the angiotensinogen gene were used to determine the association between two-locus angiotensinogen gene polymorphisms and hypertension.</p><p><b>RESULTS</b>As to the risk to high blood pressure and high systolic pressure, women with MM genotype were 7.7 (95% CI 1.3-20.5) and 8.7 (95% CI 1.8-20.1) times higher than those with TT genotype after adjustment for age and body mass index. Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.</p><p><b>CONCLUSION</b>Our results suggest that angiotensinogen gene 235MM is a predictor for hypertension development in Tibetan women but not in men, and may exert its hypertensive effect on linkage disequilibrum with a possible function locus of G-6A.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Renin-Angiotensin System
/
Haplotypes
/
Polymorphism, Restriction Fragment Length
/
DNA
/
Case-Control Studies
/
China
/
Sex Factors
/
Angiotensinogen
/
Polymerase Chain Reaction
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2004
Type:
Article
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