Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 203-208, 2004.
Article
in English
| WPRIM
| ID: wpr-329641
ABSTRACT
<p><b>OBJECTIVE</b>To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.</p><p><b>METHODS</b>One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.</p><p><b>RESULTS</b>The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.</p><p><b>CONCLUSION</b>HLA-B*46 may be associated with its susceptibility to HIV-1 infections.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virulence
/
Blood
/
DNA
/
HLA-B Antigens
/
Ethnicity
/
Case-Control Studies
/
HIV Infections
/
China
/
Polymerase Chain Reaction
/
Surveys and Questionnaires
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2004
Type:
Article
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