Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
Acta Pharmaceutica Sinica B
;
(6): 141-145, 2014.
Article
in English
| WPRIM
| ID: wpr-329743
ABSTRACT
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
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Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Acta Pharmaceutica Sinica B
Year:
2014
Type:
Article
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