Histidine triad nucleotide-binding protein 1 and human diseases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 454-460, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329804
ABSTRACT
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid. HINT1 is implicated in pathological progress of many human diseases including cancer and schizophrenia; however, little is known about the essential role and pathological consequences of HINT1 in cellular physiology and diseases. Therefore, we summarize the structure, distribution, and physiological function of HINT1 in cells and tissues as well as the correlation between HINT1 and human diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Disease
/
Nerve Tissue Proteins
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2014
Type:
Article
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