A voxel-based morphometry study of grey matter volume changes in neuromyelitis optica patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 432-438, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-329808
ABSTRACT
<p><b>OBJECTIVE</b>To explore the grey matter volume (GMV) changes in neuromyelitis optica (NMO) patients using a voxel-based morphometry method.</p><p><b>METHODS</b>Whole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls. Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8.</p><p><b>RESULT</b>Compared with the controls, NMO patients showed decreased GMV in the frontal lobe, parietal lobe, temporal lobe, occipital lobe, limbic lobe, optic tract, caudate nucleus, thalamus, and cerebellum (all P < 0.005).</p><p><b>CONCLUSIONS</b>Regional atrophy of grey matter is found in NMO patients. Voxel-based morphometry can reveal brain volume changes sensitively.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Magnetic Resonance Imaging
/
Case-Control Studies
/
Neuromyelitis Optica
/
Gray Matter
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2014
Type:
Article
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