Expression related to vascular endothelial growth factor C and induced nitride oxide synthesizase in lymph node micrometastasis of oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 445-459, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-330025
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of vascular endothelial growth factor C (VEGF-C) and induced nitride oxide synthesizase (iNOS) expression in lymph node micrometastasis of oral squamous cell carcinoma.</p><p><b>METHODS</b>Samples were obtained from 47 cases of oral squamous cell carcinoma and 15 cases with normal oral mucosa, VEGF-C and iNOS mRNA expression were detected by RT-PCR method. Lymph node micrometastasis of 10 normal lymph nodes and 355 lymph nodes from 47 cases of oral squamous cell carcinoma was detected with immunohistochemical reaction in cytokeratin antibody.</p><p><b>RESULTS</b>The percentages in tumors with higher expression were 57.4% for VEGF-C, 68.1% for iNOS (P < 0.05). They were significantly higher than that of normal groups. Significant positive relationship was found between VEGF-C and iNOS (P < 0.01). The positive rate of cytokeratin (CK) was 48.9%. Significant positive relationship was found between VEGF-C and CK, iNOS and CK (P < 0.01). The expression rates of CK in positive group of VEGF-C and iNOS were 63.0%, 65.6% respectively, and were significant higher than negative groups.</p><p><b>CONCLUSION</b>Expression of VEGF-C and iNOS in lymph node micrometastasis of oral squamous cell carcinoma is significant related.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Vascular Endothelial Growth Factor C
/
Nitric Oxide Synthase Type II
/
Neoplasm Micrometastasis
/
Keratins
/
Lymphatic Metastasis
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2004
Type:
Article
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