Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2684-2688, 2014.
Article
in Zh
| WPRIM
| ID: wpr-330270
Responsible library:
WPRO
ABSTRACT
The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-beta-0-4'-conifery ether (1), lirioresinol A (2), 1-hydroxypinoresinol (3), 5-methoxybalanophonin (4), balanophonin (5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol (6), and p-hydroxybenzaldehyde (7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7 (1 x 10(-12)-1 x 10(-7) mol x L(-1)) increased UMR106 cell proliferation to some extent.
Full text:
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Index:
WPRIM
Main subject:
Osteoblasts
/
Pharmacology
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Cell Line
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Chemistry
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Lignans
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Plant Stems
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Sambucus
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Cell Biology
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Cell Proliferation
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article