A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2674-2678, 2014.
Article
in English
| WPRIM
| ID: wpr-330272
ABSTRACT
A new flavonone, named as (2R, 3S)-pinobanksin-3-cinnamate(1), together with six known compounds, pinocem-brin (2), pinobanksin (3), 3-O-acetylpinobanksin (4), galangin (5), kumatakenin(6), and 3-methylkaempferol (7), were isolated from a 95% ethanol extract of seeds of Alpinia katsumadai through a combination of various chromatographic techniques, including silica gel and Sephadex LH-20. The structure of compound 1 was elucidated by spectroscopic data analysis. Compound 1 exhibits a potent neuroprotective effect against the corticosterone-damaged PC12 cells, which may be underlying the effect by scavenging intracellular ROS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Seeds
/
Chemistry
/
Cholestenones
/
Cinnamates
/
PC12 Cells
/
Cell Death
/
Reactive Oxygen Species
/
Oxidative Stress
/
Neuroprotective Agents
Limits:
Animals
Language:
English
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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