Advance in studies on toxicity of aristolochic acid and analysis on risk factors / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2246-2250, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-330312
ABSTRACT
The renal toxicity and mutagenicity of aristolochic acid (AA) as well as its carcinogenicity on upper urinary tract transitional epithelial cells have been widely known. Since 2003, drug regulatory departments have successively cancelled the quality standards for AA-containing medicines such as Aristolochiae Radix, Aristolochiae Manshuriensis Caulis and Aristolchiae Fangchi Radix, and adopted measures for strengthening regulation and revising package insert or quality standards for other AA-containing medicines, including Aristolochia Cinnabarina Radix, Aristolochiae Fructus, Aristolochiae Mollissimae Herba, in order to control its safety risk. In recent years, domestic and foreign studies on AA have mainly involved action mechanism and clinical performance of AA toxicity, early-stage diagnosis and treatment method. In this paper, authors gave a brief summary and evaluation on risk factors for using AA-containing medicines, and offered measures and suggestions for preventing and controlling AA toxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Chemistry
/
Epidemiology
/
Aristolochia
/
Aristolochic Acids
/
Therapeutic Uses
/
Drug Therapy
/
Drug-Related Side Effects and Adverse Reactions
/
Toxicity
Type of study:
Etiology study
/
Practice guideline
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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