Experimental study on relationship between pungent-hot herb property express and calmodulin / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 873-878, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-330344
ABSTRACT
<p><b>OBJECTIVE</b>To explain the essence of pungent-hot herb property express according to in vivo and in vitro studies on its effect on calmodulin on the base of the observation of the adjustment in hypothalamic-pituitary-gonad axis functions of Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex in rats under the state of yang deficiency.</p><p><b>METHOD</b>The yang-deficient model was duplicated by intramuscularly injecting hydrocortisone sodium succinate powder injection. After the intervention with Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex for seven days, TSH, T3, T4, 17-OHCS, COR, T, E2 of hypothalamus-pituitary-target gland axis and other relevant indexes were detected. The calmodulin expression in livers and L02 cells cultured in vitro was detected by using Western blot.</p><p><b>RESULT</b>Pungent-hot herbs Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex can significantly correct indicators of hypothalamic-pituitary-gonad axis and calmodulin, whereas the bitter-cold herb Phellodendri Chinensis Cortex showed no obvious effect.</p><p><b>CONCLUSION</b>The pungent-hot herb property expression may be closely related to calmodulin.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Calmodulin
/
Drugs, Chinese Herbal
/
Chemistry
/
Yang Deficiency
/
Rats, Sprague-Dawley
/
Drug Therapy
/
Gonads
/
Hypothalamo-Hypophyseal System
/
Liver
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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