Study on hydrolysis kinetics of ginsenoside-Ro in alkaline medium and structural analysis of its hydrolyzate / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 867-872, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-330345
ABSTRACT
The ginsenoside-Ro is sensitive to be hydrolyzed in an alkaline medium. This paper investigated the hydrolysis kinetics of ginsenoside-Ro under different pH and temperature values. The results showed ginsenoside-Ro in alkaline solution followed pseudo-first-order reaction. Hydrolysis kinetics of ginsenoside-Ro has not been reported previously. The hydrolysis rate was independent of initial concentration. On the basis of UFLC-MS/MS, NMR, as well as chemical evidence,the structure of hydrolyzate was assigned as 3-O- [beta-D-glucuronopyranosyl- (1 --> 2) -beta-D-glucopyranosyl] -oleanolic acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Drugs, Chinese Herbal
/
Kinetics
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Spectrometry, Mass, Electrospray Ionization
/
Ginsenosides
/
Hydrogen-Ion Concentration
/
Hydrolysis
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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