Correlation of ornidazole concentration in saliva and serum of healthy volunteers / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2108-2110, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-330770
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.</p><p><b>METHODS</b>Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.</p><p><b>RESULTS</b>The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.</p><p><b>CONCLUSION</b>Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ornidazole
/
Saliva
/
Blood
/
Pharmacokinetics
/
Feasibility Studies
/
Chromatography, High Pressure Liquid
/
Metabolism
/
Anti-Bacterial Agents
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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