Therapeutic efficacy of Nexavar on liver cancer and its relation to the expression of Ki-67 and CD34 / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the therapeutic effects of Nexavar on liver cancer and its relation to the expressions of Ki-67 and CD34.</p><p><b>METHODS</b>Twenty-eight patients with liver cancer were treated with Nexavar. The therapeutic efficacy of Nexavar on liver cancer was observed. Liver cancer tissues were examined for the expressions of Ki-67 and CD34 by immunohistochemistry. Microvessel density (MVD) was calculated according to the expression of CD34.</p><p><b>RESULTS</b>Of 28 patients, none achieved a complete response (CR), 12 had a partial response (PR), 7 had stable disease (SD), and 9 progressive disease (PD). The efficacy of Nexavar was associated significantly with Ki-67 expression. The mean MVD count was 346.03-/+146.98 in PR patients, and 89.14-/+45.66 in PD patients. There was a significant difference in MVD between PR and PD patients.</p><p><b>CONCLUSION</b>There is a better efficacy of Nexavar in treatment of liver cancer in the patients who had Ki-67-positive expression and high MVD count.</p>