Your browser doesn't support javascript.
loading
Correlation between blood cAMP, cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 68-70, 2004.
Article in English | WPRIM | ID: wpr-330869
ABSTRACT
In order to investigate the correlation between traumatic servity and blood cAMP and cGMP levels in the patients with acute trauma and its clinical significance, 120 cases of trauma were randomly selected and divided into 4 groups (n = 30 in each group) mildly traumatic group (ISS < or = 9), moderately traumatic group (ISS = 10-16), severely traumatic group (ISS = 17-25) and dangerously traumatic group (> 25). The cAMP and cGMP levels were assayed in sera, leucocytes and platelets respectively in 6 h and 24 h after trauma. The results showed that cAMP and cGMP levels were elevated significantly in sera and platelets (P < 0.05 or P < 0.01), meanwhile cGMP levels in leucocytes (P < 0.05). It was concluded that cAMP and cGMP might play an important role in traumatic stress, participate in the cellular signal transducation and promote the immune function of leucocytes and the coagulation founction of platelets. Serum cAMP and cGMP levels were upregulated correspondingly as ISS increased, and positively correlated to the traumatic severity.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Wounds and Injuries / Blood / Blood Platelets / Injury Severity Score / Cyclic AMP / Cyclic GMP / Leukocytes / Metabolism Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2004 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Wounds and Injuries / Blood / Blood Platelets / Injury Severity Score / Cyclic AMP / Cyclic GMP / Leukocytes / Metabolism Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2004 Type: Article