Research progress and application of BCR/ABL transgenic animal model / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1532-1535, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-331039
ABSTRACT
Transgenic animal model provide a good platform to research the pathogenesis and therapy of chronic myelogenous leukemia (CML). To date, a number of BCR/ABL transgenic animal models have been established using different promoter or tetracycline-controlling system. Some of them appear the characteristics of human CML, which have contributed greatly to research the pathogenesis and therapy of CML. In this article, the researching progress, advantage and drawback, application of BCR/ABL transgenic animal model are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Animals, Genetically Modified
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Fusion Proteins, bcr-abl
/
Disease Models, Animal
/
Genetics
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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