Research progress in heterogeneity of human CD4(+)FOXP3(+)T cells / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1528-1531, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-331040
ABSTRACT
It is now established that CD4(+)CD25(+)regulatory T (Treg) cells expressing transcription factor FOXP3, a regulatory subpopulation of T cells, is indispensable for the maintenance of immunological self-tolerance and immune homeostasis. FOXP3 expression in Treg cells is specific and it is the key control factor for the development, activation and function of Treg cells. At present, CD4(+)FOXP3(+)T lymphocytes are often used to define Treg cells for scientific research. But recent studies show that human CD4(+)FOXP3(+)T cells are phenotypically and functionally heterogeneous, including suppressive and non suppressive T cells. The different functions of these cell subsets can be distinguished by phenotypic differences. This review discusses the recent research progress about phenotypic characteristics and functional heterogeneity of CD4(+)FOXP3(+)T cell subsets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes, Regulatory
/
Allergy and Immunology
/
Forkhead Transcription Factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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