HLA-A, B and DRB1 polymorphism at high-resolution in Han population from southern area of Shandong province in China / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1482-1488, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-331050
ABSTRACT
This study was aimed to analyze the polymorphism of HLA-A, B, DRB1 alleles at high-resolution level in Han population from southern area of Shandong province in China. 688 randomly selected, unrelated and healthy individual from southern area of Shandong province were genotyped for HLA-A, -B and HLA-DRB1 loci by PCR-SBT. Then, allelic and haplotypic distributions of HLA-A, B and DRB1 were estimated by maximum likelihood estimation method using Arlequin 3.0. The results indicated that a total of 31 HLA-A, 63 HLA-B and 39 HLA-DRB1 alleles were identified in Han Population from southern area of Shandong province. Six HLA-A alleles were found with a frequency greater than 0.05 (A*2402, *3001, *1101, *0201, *3303 and *0206), with a cumulative frequency of 0.7223. For HLA-B locus, there were also six alleles which had a frequency higher than 5% (B*1302, *4403, *5101, B*4601, *1501 and *5801), representing 0.4432 of the all alleles in the population. And four HLA-DRB1 alleles were defined as predominant (DRB1*0701, *1501, *0901and *0803), accounting for 0.5453 of the defined alleles. The most common three-loci haplotype was A*3001-B*1302-DRB1*0701 (0.1151) and the most frequent two-loci haplotype were A*3001-B*1302 (0.1303), A*3001-DRB1*0701 (0.1157) and B*1302-DRB1*0701 (0.1307). It is concluded that the allelic and haplotypic diversities of HLA-A, -B and HLA-DRB1 at high-resolution in Han population from southern area of Shandong province in China provide useful information for HLA matching in transplantation and diseases-associated study in this population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Haplotypes
/
HLA-A Antigens
/
HLA-B Antigens
/
China
/
Asian People
/
Alleles
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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