Correlation between ATP bioluminescence tumor chemosensitivity assay and clinical response in ovarian cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 296-298, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-331165
ABSTRACT
<p><b>OBJECTIVE</b>To determine the correlation between results of ATP bioluminescence tumor chemosensitivity assay (ATP-TCA) of human ovarian cancer specimens in vitro and clinical chemo-therapeutic responses of patients.</p><p><b>METHODS</b>Thirty-four freshly taken ovarian cancer specimens (28 cases) and ascites (6 cases) and 9 chemotherapeutic drugs were tested in vitro for cancer chemosensitivity by ATP-TCA.</p><p><b>RESULTS</b>Among the 34 ovarian cancer cases, the efficacy of ATP-TCA is 94.0%, the sensitivity, the specificity, the positive and negative predicting values, and an overall predicting value in vitro and vivo were 90.0%, 91.7%, 94.7%, 84.6% and 90.6%, respectively.</p><p><b>CONCLUSION</b>The results of ATP-TCA assay are correlated well with clinical treatment responses. The assay may be an important and useful method for individual-based chemotherapy of cancers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Pathology
/
Pharmacology
/
Drug Screening Assays, Antitumor
/
Carcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Adenosine Triphosphate
/
Predictive Value of Tests
/
Sensitivity and Specificity
/
Cisplatin
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2005
Type:
Article
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