Apoptosis-related gene expression and its clinical significance of human osteosarcoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 678-681, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-331233
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic markers in osteosarcoma.</p><p><b>METHODS</b>Expressions of p53, c-myc, bcl-2 and apoptosis index (AI) in 28 osteosarcoma specimens were detected by ABC immunohistochemistry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labelling (TUNEL). The relationship between gene expression and apoptosis, and their correlations with pathologic classification and prognostic factors were analyzed.</p><p><b>RESULTS</b>There was negative correlation between the expressions of p53, c-myc, bcl-2 protein and AI, which was closely related to the long term survival of patients but was not related to pathologic types of the tumor.</p><p><b>CONCLUSION</b>The expressions of p53, c-myc, bcl-2 protein and AI can be used as an index for predicting the progression and prognosis of osteosarcoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Bone Neoplasms
/
Biomarkers, Tumor
/
Osteosarcoma
/
Survival Rate
/
Follow-Up Studies
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Disease Progression
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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