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Apoptosis-related gene expression and its clinical significance of human osteosarcoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 678-681, 2004.
Article in Chinese | WPRIM | ID: wpr-331233
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic markers in osteosarcoma.</p><p><b>METHODS</b>Expressions of p53, c-myc, bcl-2 and apoptosis index (AI) in 28 osteosarcoma specimens were detected by ABC immunohistochemistry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labelling (TUNEL). The relationship between gene expression and apoptosis, and their correlations with pathologic classification and prognostic factors were analyzed.</p><p><b>RESULTS</b>There was negative correlation between the expressions of p53, c-myc, bcl-2 protein and AI, which was closely related to the long term survival of patients but was not related to pathologic types of the tumor.</p><p><b>CONCLUSION</b>The expressions of p53, c-myc, bcl-2 protein and AI can be used as an index for predicting the progression and prognosis of osteosarcoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Bone Neoplasms / Biomarkers, Tumor / Osteosarcoma / Survival Rate / Follow-Up Studies / Tumor Suppressor Protein p53 / Apoptosis / Disease Progression Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Bone Neoplasms / Biomarkers, Tumor / Osteosarcoma / Survival Rate / Follow-Up Studies / Tumor Suppressor Protein p53 / Apoptosis / Disease Progression Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2004 Type: Article