Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance.</p><p><b>METHODS</b>In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR.</p><p><b>RESULTS</b>The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05).</p><p><b>CONCLUSION</b>CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis.</p>