Long-term effects of bone marrow-derived cells transplantation in patients with acute myocardial infarction: a meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 353-360, 2013.
Article
in English
| WPRIM
| ID: wpr-331268
ABSTRACT
<p><b>BACKGROUND</b>The long-term effects of bone marrow-derived cells (BMC) transplantation in patients with acute myocardial infarction (AMI) have not been established. The present meta-analysis of randomized controlled trials with follow-up ≥ 2 years was performed to investigate the long-term effects of BMC therapy in patients after AMI.</p><p><b>METHODS</b>Specific terms were used to conduct a systematic literature search of MEDLINE, EMBASE, the Cochrane Library and the Cochrane Central Register of Controlled Trials, and the China Biological Medicine Disk database from their inception to March 2012. A standardized protocol was used to extract information, and random effect model was used to analyze all data except major adverse events.</p><p><b>RESULTS</b>Five trials comprising 510 patients were included. Compared with controls, BMC therapy significantly improved left ventricular ejection fraction (LVEF) (4.18%, 95%CI 2.02% to 6.35%, P = 0.0002), while mildly but not significantly reduced left ventricular end-systolic volume (-4.47 ml, 95%CI -10.92 to 1.99, P = 0.17) and left ventricular end-diastolic volume (-2.29 ml, 95%CI -9.96 to 5.39, P = 0.56). Subgroup analysis revealed that significant improvement of LVEF induced by BMC therapy could be observed in patients with baseline LVEF ≤ 42%, but disappeared in those with baseline LVEF > 42%. There were trends in favor of BMC therapy for most major clinical adverse events, though most differences were not significant.</p><p><b>CONCLUSIONS</b>Intracoronary BMC infusion in patients with AMI seems to be safe and may further improve LVEF on top of standard therapy; especially the beneficial effects could last for long term. The findings need to be validated in the future.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Randomized Controlled Trials as Topic
/
Acute Disease
/
Ventricular Function, Left
/
Bone Marrow Transplantation
/
Myocardial Infarction
Type of study:
Controlled clinical trial
/
Practice guideline
/
Prognostic study
/
Systematic reviews
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2013
Type:
Article
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