Glutamate receptor-mediated retinal neuronal injury in experimental glaucoma / 生理学报
Acta Physiologica Sinica
;
(6): 483-491, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-331637
ABSTRACT
Glaucoma, the second leading cause of blindness, is a neurodegenerative disease characterized by optic nerve degeneration related to apoptotic death of retinal ganglion cells (RGCs). In the pathogenesis of RGC death following the onset of glaucoma, functional changes of glutamate receptors are commonly regarded as important risk factors. During the past several years, we have explored the mechanisms underlying RGC apoptosis and retinal Müller cell reactivation (gliosis) in a rat chronic ocular hypertension (COH) model. We demonstrated that elevated intraocular pressure in COH rats may induce changes of various signaling pathways, which are involved in RGC apoptosis by modulating glutamate NMDA and AMPA receptors. Moreover, we also demonstrated that over-activation of group I metabotropic glutamate receptors (mGluR I) by excessive extracellular glutamate in COH rats could contribute to Müller cell gliosis by suppressing Kir4.1 channels. In this review, incorporating our results, we discuss glutamate receptor- mediated RGC apoptosis and Müller cell gliosis in experimental glaucoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Retinal Ganglion Cells
/
Glaucoma
/
Ocular Hypertension
/
Receptors, Glutamate
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2016
Type:
Article
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