Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease / 生理学报
Acta Physiologica Sinica
;
(6): 201-206, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-331665
ABSTRACT
microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cardiovascular Diseases
/
Cell Differentiation
/
Apoptosis
/
MicroRNAs
/
Endothelial Cells
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2016
Type:
Article
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