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Mechanism of cardiac atrophy under weightlessness/simulated weightlessness / 生理学报
Acta Physiologica Sinica ; (6): 194-200, 2016.
Article in Zh | WPRIM | ID: wpr-331666
Responsible library: WPRO
ABSTRACT
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca(2+)-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Atrophy / Space Flight / Weightlessness / NF-kappa B / Weightlessness Simulation / Heart / Heart Diseases / Hemodynamics Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Acta Physiologica Sinica Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Atrophy / Space Flight / Weightlessness / NF-kappa B / Weightlessness Simulation / Heart / Heart Diseases / Hemodynamics Type of study: Prognostic_studies Limits: Humans Language: Zh Journal: Acta Physiologica Sinica Year: 2016 Type: Article