Mechanism of cardiac atrophy under weightlessness/simulated weightlessness / 生理学报
Acta Physiologica Sinica
; (6): 194-200, 2016.
Article
in Zh
| WPRIM
| ID: wpr-331666
Responsible library:
WPRO
ABSTRACT
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca(2+)-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
Full text:
1
Index:
WPRIM
Main subject:
Atrophy
/
Space Flight
/
Weightlessness
/
NF-kappa B
/
Weightlessness Simulation
/
Heart
/
Heart Diseases
/
Hemodynamics
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2016
Type:
Article