Study on the intercellular molecule-1 polymorphisms in an Chinese population with myocardial infarction / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 702-706, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-331801
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between intercellular adhesion molecule-1 (ICAM-1) gene + 12959G/A and + 13848A/G polymorphism and myocardial infarction (MI).</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primers (PCR-SSP) technology and PCR-restriction fragment length polymorphism(PCR-RFLP) were used for the detection of ICAM-1 genotypes in 165 patients with MI(including acute MI and old MI) and 199 healthy controls. Plasma lipid levels and hyper sensitive C reactive protein (quantitive ELISA method was used) levels were measured in all subjects.</p><p><b>RESULTS</b>+ 12959G/A polymorphism was not detected in our study. The frequencies of AA,AG and GG Genotypes of + 13848A/G were 58.2% and 45.7%, 37.0% among patients and 45.2%, 4.8% and 9.0% among controls,respectively. There were statistically significant differences in the distributions of the genotype frequencies (P<0.05) between two groups, and the relative risk suffered from MI of AA genotype was 1.651 times of the GG and GA genotype (OR = 1.651, 95% CI 1.089-2.504).</p><p><b>CONCLUSION</b>There was no + 12959G/A polymorphism found in Chinese people. The coding single nucleotide polymorphism + 13848 A/G in the exon 6 of ICAM-1 gene was associated to MI and the allele A might serve as a risk factor for MI in Chinese.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
China
/
Polymerase Chain Reaction
/
Intercellular Adhesion Molecule-1
/
Polymorphism, Single Nucleotide
/
Asian People
/
Gene Frequency
/
Genetics
/
Genotype
/
Myocardial Infarction
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2005
Type:
Article
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