Analysis on synergistic action between estrogen, progesterone and human papillomaviruses in cervical cancer / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 370-373, 2005.
Article
in Zh
| WPRIM
| ID: wpr-331874
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of estrogen (E(2)) and progesterone (P) on cervical cancer and the synergistic action between estrogen, progesterone and human papillomaviruses (HPV).</p><p><b>METHODS</b>Hoted-start polymerase chain reaction (HS-PCR) was used to detect HPVs, HPV16 and ELISA was used to assay E(2) and P on 141 cases with cervical cancer and on 129 healthy controls.</p><p><b>RESULTS</b>Positive rates of HPVs and HPV16 were 75.2% and 46.8% respectively in cervical cancer group, significantly higher than that in controls. Levels of estrogen and progesterone in case group were significantly higher than that in controls and a dose-responded relationship between the levels of estrogen and cervical cancer was revealed. Estrogen and HPV showed an additive interaction in the development of cervical cancer.</p><p><b>CONCLUSION</b>HPV16 infection played a principal role in the development of cervical cancer. The high levels of entogenous estrogen could increase the risk of cervical cancer and might serve as a cofactor in the development of HPV-induced cervical cancer.</p>
Full text:
1
Index:
WPRIM
Main subject:
Progesterone
/
Virology
/
Blood
/
DNA, Viral
/
Enzyme-Linked Immunosorbent Assay
/
Uterine Cervical Neoplasms
/
China
/
Polymerase Chain Reaction
/
Epidemiology
/
Risk Factors
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2005
Type:
Article