Effect of Bufei Qingyu Granule in mollifying skin of mouse scleroderma model / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect and mechanism of Bufei Qingyu Granule (BQG) in mollifying the skin of scleroderma model mice.</p><p><b>METHODS</b>Scleroderma model induced with bleomycin in BALB/C mice 8-weeks old were administered with different dose of BQG for 26 days. The pathological changes of the mice skin were observed.</p><p><b>RESULTS</b>Treatment with low, medium and high dose of BQG showed a tendency to ameliorate the thickened dermis in scleroderma mice but without statistical significance. Medium and high dose of BQG reduced the perivasculitis of dermis and alleviated the reduction or deletion of accessory structure, such as hair follicle and sweat gland. And the spleen index was lower markedly in mice treated with BQG of any dose than that in the untreated model mice (P < 0.05).</p><p><b>CONCLUSION</b>BQG could ameliorate the sclerosed skin in model mice and prevent the occurrence of splenomegaly.</p>