Effect of the disassembled recipes of dahuang zhechong pill on proliferation and apoptosis of vascular smooth muscle cells in atherosclerotic rabbits / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 913-917, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-331952
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of the disassembled recipes of Dahuang Zhechong Pill (DRDZP) on proliferation and apoptosis of vascular smooth muscle cell (VSMC) of thoracic aorta in atherosclerotic rabbits.</p><p><b>METHODS</b>The atherosclerotic rabbit model was induced by high-cholesterol diet and immune injury of endothelium. Expression of proliferating cell nuclear antigen (PCNA) in VSMC was detected by SP immunohistochemical technique, and VSMC apoptosis was observed with TUNEL technique.</p><p><b>RESULTS</b>Compared with the model control, PCNA expression in VSMC decreased, while apoptotic cells increased significantly in all the groups treated by DR-DZP (P < 0.01).</p><p><b>CONCLUSION</b>All the DR-DZP could inhibit VSMC proliferation and promote its apoptosis to modulate the balance between cell proliferation and apoptosis, so as to exert antiatherosclerotic action, among which the disassembled-recipe I is the main composition to contribute to antiatherosclerotic action of Dahuang Zhechong Pill.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Thoracic
/
Pathology
/
Pharmacology
/
Drugs, Chinese Herbal
/
Immunohistochemistry
/
Cells, Cultured
/
Apoptosis
/
Proliferating Cell Nuclear Antigen
/
In Situ Nick-End Labeling
/
Myocytes, Smooth Muscle
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2006
Type:
Article
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